In vivo modeling of biofilm-infected wounds: a review

AK Seth, MR Geringer, SJ Hong, KP Leung… - Journal of surgical …, 2012 - Elsevier
Chronic wounds continue to represent a difficult and complex problem for both patients and
healthcare providers. Bacterial biofilms represent a critical component of nonhealing …

Time course study of delayed wound healing in a biofilm‐challenged diabetic mouse model

G Zhao, ML Usui, RA Underwood… - Wound Repair and …, 2012 - Wiley Online Library
Bacterial biofilm has been shown to play a role in delaying wound healing of chronic
wounds, a major medical problem that results in significant health care burden. A …

Comparative Analysis of Single-Species and Polybacterial Wound Biofilms Using a Quantitative, In Vivo, Rabbit Ear Model

AK Seth, MR Geringer, SJ Hong, KP Leung… - 2012 - journals.plos.org
Introduction The recent literature suggests that chronic wound biofilms often consist of
multiple bacterial species. However, without appropriate in vivo, polybacterial biofilm …

Treatment of Pseudomonas aeruginosa biofilm–infected wounds with clinical wound care strategies: a quantitative study using an in vivo rabbit ear model

AK Seth, MR Geringer, AN Gurjala… - Plastic and …, 2012 - journals.lww.com
Background: Bacterial biofilm is recognized as a major detriment to wound healing. The
efficacy of traditional wound care against biofilm has never been studied. The authors …

Increasing the presence of biofilm and healing delay in a porcine model of MRSA‐infected wounds

ED Roche, PJ Renick, SP Tetens… - Wound repair and …, 2012 - Wiley Online Library
Data supporting the concept that microbial biofilms are a major cause of non‐healing ulcers
remain limited. A porcine model was established where delayed healing resulted from …

Quantitative comparison and analysis of species-specific wound biofilm virulence using an in vivo, rabbit-ear model

AK Seth, MR Geringer, RD Galiano, KP Leung… - Journal of the American …, 2012 - Elsevier
BACKGROUND: Although bacterial biofilm is recognized as an important contributor to
chronic wound pathogenesis, differences in biofilm virulence between species have never …

An improved medium for growing Staphylococcus aureus biofilm

P Chen, JJ Abercrombie, NR Jeffrey… - Journal of microbiological …, 2012 - Elsevier
A medium (Brain Heart Infusion plus 10% human plasma) was developed, tested, and
validated for growing Staphylococcus aureus biofilm in vitro. With this medium, S. aureus …

Potential implications of biofilm in chronic wounds: a case series

J Hurlow, PG Bowler - Journal of wound care, 2012 - magonlinelibrary.com
Bacterial biofilm is increasingly suspected as being a significant barrier to wound healing.
Bacteria predominantly attach to surfaces in their natural habitats and form biofilm; in this …

Applicability of confocal laser scanning microscopy for evaluation and monitoring of cutaneous wound healing

S Lange-Asschenfeldt, A Bob… - … of biomedical optics, 2012 - spiedigitallibrary.org
There is a high demand for noninvasive imaging techniques for wound assessment. In vivo
reflectance confocal laser scanning microscopy (CLSM) represents an innovative optical …

Laser irradiation effect on Staphylococcus aureus and Pseudomonas aeruginosa biofilms isolated from venous leg ulcer

M Baffoni, LJ Bessa, R Grande… - International Wound …, 2012 - Wiley Online Library
Chronic wounds, including diabetic foot ulcers, pressure ulcers and venous leg ulcers,
represent a significant cause of morbidity in developed countries, predominantly in older …