Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …

Mammals exhibit multiple adaptive mechanisms that sense and respond to fluctuations in
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is …

DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription
factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress …

Purpose.: The human rhodopsin (Rho) mutation T17M leads to autosomal dominant retinitis
pigmentosa (adRP). The goal of our study was to elucidate the role of endoplasmic reticulum …

Purpose.: Endoplasmic reticulum (ER) stress has been observed in animal models of
retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced ER …

The incidence of acute kidney injury (AKI) is very high, and multiple physiopathological
processes are involved, including endoplasmic reticulum stress (ERS) …

Different environmental stresses induce the phosphorylation of eIF2 (eIF2∼ P), repressing
global protein synthesis coincident with preferential translation of ATF4. ATF4 is a …

Keratosis linearis with ichthyosis congenita and keratoderma (KLICK) is an autosomal
recessive skin disorder associated with a single-nucleotide deletion in the 5′ untranslated …

Introduction: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising
death ligand who has received significant attention due to its specific anti-cancer activity …

Aims Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic
reticulum (SR) Ca2+ release by interacting with the ryanodine receptor. The levels of these …