Subcellular targets of cisplatin cytotoxicity: an integrated view
SM Sancho-Martínez, L Prieto-García, M Prieto… - Pharmacology & …, 2012 - Elsevier
Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …
[HTML][HTML] The transcription factor network associated with the amino acid response in mammalian cells
MS Kilberg, M Balasubramanian, L Fu, J Shan - Advances in nutrition, 2012 - Elsevier
Mammals exhibit multiple adaptive mechanisms that sense and respond to fluctuations in
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is …
dietary nutrients. Consumption of reduced total dietary protein or a protein diet that is …
Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153
A Jauhiainen, C Thomsen, L Strömbom, P Grundevik… - PloS one, 2012 - journals.plos.org
DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription
factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress …
factor of the dimer forming C/EBP family. DDIT3 is known as a key regulator of cellular stress …
ER stress is involved in T17M rhodopsin-induced retinal degeneration
MM Kunte, S Choudhury, JF Manheim… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: The human rhodopsin (Rho) mutation T17M leads to autosomal dominant retinitis
pigmentosa (adRP). The goal of our study was to elucidate the role of endoplasmic reticulum …
pigmentosa (adRP). The goal of our study was to elucidate the role of endoplasmic reticulum …
Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration
H Kroeger, C Messah, K Ahern, J Gee… - … & visual science, 2012 - iovs.arvojournals.org
Purpose.: Endoplasmic reticulum (ER) stress has been observed in animal models of
retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced ER …
retinitis pigmentosa expressing P23H rhodopsin. We compared levels of tightly induced ER …
The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion‐induced acute kidney injury by inhibiting endoplasmic reticulum stress
X Gao, L Fu, M Xiao, C Xu, L Sun… - Basic & clinical …, 2012 - Wiley Online Library
The incidence of acute kidney injury (AKI) is very high, and multiple physiopathological
processes are involved, including endoplasmic reticulum stress (ERS) …
processes are involved, including endoplasmic reticulum stress (ERS) …
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response
S Dey, S Savant, BF Teske, M Hatzoglou… - Journal of Biological …, 2012 - ASBMB
Different environmental stresses induce the phosphorylation of eIF2 (eIF2∼ P), repressing
global protein synthesis coincident with preferential translation of ATF4. ATF4 is a …
global protein synthesis coincident with preferential translation of ATF4. ATF4 is a …
siRNA Silencing of Proteasome Maturation Protein (POMP) Activates the Unfolded Protein Response and Constitutes a Model for KLICK Genodermatosis
Keratosis linearis with ichthyosis congenita and keratoderma (KLICK) is an autosomal
recessive skin disorder associated with a single-nucleotide deletion in the 5′ untranslated …
recessive skin disorder associated with a single-nucleotide deletion in the 5′ untranslated …
Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis
MD Siegelin - Expert opinion on therapeutic targets, 2012 - Taylor & Francis
Introduction: Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a promising
death ligand who has received significant attention due to its specific anti-cancer activity …
death ligand who has received significant attention due to its specific anti-cancer activity …
Ablation of junctin or triadin is associated with increased cardiac injury following ischaemia/reperfusion
WF Cai, T Pritchard, S Florea, CK Lam… - Cardiovascular …, 2012 - academic.oup.com
Aims Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic
reticulum (SR) Ca2+ release by interacting with the ryanodine receptor. The levels of these …
reticulum (SR) Ca2+ release by interacting with the ryanodine receptor. The levels of these …