To advance our understanding and treatment of disease, research immunologists have
been called-upon to place more centralized emphasis on impactful human studies. Such …

Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin
production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the …

The immunological roles of B-cells are being revealed as increasingly complex by functions
that are largely beyond their commitment to differentiate into plasma cells and produce …

Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb
repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of …

The cellular origin of chronic lymphocytic leukemia (CLL) is still debated, although this
information is critical to understanding its pathogenesis. Transcriptome analyses of CLL and …

The four serotypes of dengue virus (DENV) cause dengue fever (DF) and dengue
hemorrhagic fever/dengue shock syndrome (DHF/DSS). Severe disease has been …

B cells infiltrate the skin in many chronic inflammatory diseases caused by autoimmunity or
infection. Despite potential contribution to disease, skin-associated B cells remain poorly …

Streptococcus pneumoniae is a significant human pathogen and currently available
pneumococcal vaccines are designed to elicit anti-capsule antibodies. The 23-valent …

Humoral memory is maintained by two types of persistent cells, memory B cells and plasma
cells, which have different phenotypes and functions. Long-lived plasma cells can survive for …

Over the past decade, a growing recognition of the importance of neutralizing antibodies in
host defense combined with the success of B‐cell depletion therapies in treating auto …