Heart disease remains the leading cause of death and disability in the Western world.
Current therapies aim at treating the symptoms rather than the subcellular mechanisms …

Cardiac myocyte function is dependent on the synchronized movements of Ca2+ into and
out of the cell, as well as between the cytosol and sarcoplasmic reticulum. These …

Aims To investigate whether phospholamban gene (PLN) mutations underlie patients
diagnosed with either arrhythmogenic right ventricular cardiomyopathy (ARVC) or idiopathic …

Cantú syndrome is a rare disorder characterized by congenital hypertrichosis, neonatal
macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. Using an exome …

Heart failure (HF) is an increasing public health problem accelerated by a rapidly aging
global population. Despite considerable progress in managing the disease, the …

Spatial and temporal organization of signal transduction is coordinated through the
segregation of signaling enzymes in selected cellular compartments. This highly evolved …

The sarco (endo) plasmic reticulum calcium ATPase (SERCA) and its regulatory partner
phospholamban (PLN) are essential for myocardial contractility. Arg 9→ Cys (R9C) and Arg …

The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are
essential components of cardiac contractility. Phospholamban modulates contractility by …

Cardiomyopathies represent a group of diseases of the myocardium of the heart and include
diseases both primarily of the cardiac muscle and systemic diseases leading to adverse …

Subunit 7a of mouse cytochrome c oxidase (Cox) displays a contractile muscle-specific
isoform, Cox7a1, that is the major cardiac form. To gain insight into the role of this isoform …