Huntington's disease (HD) is a prototypical neurodegenerative disease in which there is
selective neuronal degeneration, which leads to progressive disability, manifesting itself as …

Huntington disease (HD) is a devastating neurodegenerative disease that derives from CAG
repeat expansion in the huntingtin gene. The clinical syndrome consists of progressive …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder
characterized by motor, cognitive and psychiatric manifestations. Since the mutation …

Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause
Huntington's disease (HD). Signs of endoplasmic reticulum (ER) stress have been recently …

Huntington disease (HD) is a progressive neurodegenerative monogenic disorder caused
by expansion of a polyglutamine stretch in the huntingtin (Htt) protein. Mutant huntingtin …

Backgound No disease modifying treatment currently exists for Huntington's disease (HD), a
fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates …

Transgenic systems are widely used to study the cellular and molecular basis of human
neurodegenerative diseases. A wide variety of model organisms have been utilized …

The neuropathological hallmark of the autosomal dominantly inherited, neurodegenerative
disorder Huntington's disease is progressive striatal loss starting several years prior to …

The CAG trinucleotide repeat mutation in the Huntington's disease gene (HTT) exhibits age-
dependent tissue-specific expansion that correlates with disease onset in patients …

Polyglutamine (polyQ) disorders share many similarities, such as a common mutation type in
unrelated human causative genes, neurological character, and certain aspects of …