Bone erosion is a central feature of rheumatoid arthritis and is associated with disease
severity and poor functional outcome. Erosion of periarticular cortical bone, the typical …

OBJECTIVES: To review the current literature on the regulation of bone remodelling at the
cellular level. DESIGN AND METHODS: The cellular activities of the cells in the basic …

The gut microbiota modulates host metabolism and development of immune status. Here we
show that the gut microbiota is also a major regulator of bone mass in mice. Germ‐free (GF) …

Autoimmunity is complicated by bone loss. In human rheumatoid arthritis (RA), the most
severe inflammatory joint disease, autoantibodies against citrullinated proteins are among …

Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …

Th17 cells produce IL-17, and the latter promotes bone loss in collagen-induced arthritis in
mice. Blocking IL-17 action in mouse model of rheumatoid arthritis reduces disease …

Substantial progress in understanding mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumors, organ transplantation, chronic infections, and pregnancy is in …

In periodontitis, a common chronic inflammatory condition, gram-negative-rich bacterial
biofilms trigger, in susceptible individuals, perpetuating inflammation that results in …

Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of the cross talk
between haematopoietic/immune cells and stromal cells, including the onset and resolution …

Increased osteoclastic bone resorption leads to periarticular erosions and systemic
osteoporosis in RA patients. Although a great deal is known about how osteoclasts …