In this Seminar we discuss developments from the past 5 years in the diagnosis,
neurobiology, and treatment of major depressive disorder. For diagnosis, psychiatric and …

The potential contribution of chronic inflammation to the development of neuropsychiatric
disorders such as major depression has received increasing attention. Elevated biomarkers …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …

Data suggest that cytokines released during the inflammatory response target subcortical
structures including the basal ganglia as well as dopamine function to acutely induce …

Objective The authors conducted two multicenter sequential parallel comparison design
trials to investigate the effect of l-methylfolate augmentation in the treatment of major …

CDS is an underdiagnosed behavioral problem that affects a substantial number of aged
pets. Because changes in behavior are often early indicators of medical or behavior …

Objective Antidepressants targeting monoaminergic neurotransmitter systems, despite their
immediate effects at the synaptic level, usually require several weeks of administration to …

Interest in nonpharmaceutical supplements for treating major depressive disorder (MDD)
has increased significantly, both among patients and among clinicians during the past …

Major depressive disorder (MDD) is often accompanied by significant cognitive impairment,
and there are limited interventions specific to this particular symptom. S-adenosylmethionine …

Bioavailability of S-Adenosyl Methionine and Impact on Response in a Randomized, Double-Blind,
Placebo-Controlled Trial in Major Depressive Disorder | Psychiatrist.com Advertisement …