Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Colorectal cancer is one of the most intensively studied cancer types, partly because of its
high prevalence but also because of the existence of precursor lesions, known as …

Background Locus heterogeneity is one of the most documented phenomena in genetics. To
date, relatively little work had been done on the development of methods to address locus …

A novel germline MLH1 mutation causing Lynch Syndrome in patients from the Republic of
Macedonia Page 1 496 www.cmj.hr Aim To implement molecular analysis in the clinical diagnosis …

• Over 30 familial cancer syndrome genes have been identified and genetic tests are
available for all of them.• Effective prophylactic treatments are available only for carriers of …

Identification of mutations in the mismatch repair genes of hereditary non-polyposis
colorectal cancer (HNPCC) families can lead to improved management and screening of …