The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the
p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This …

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend
off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological …

The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …

Most chronic diseases—such as cancer, cardiovascular disease (CVD), Alzheimer disease,
Parkinson disease, arthritis, diabetes and obesity—are becoming leading causes of …

The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐
κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly …

The signaling module that specifies nuclear factor‐κΒ (NF‐κB) activation is a three‐
component system: NF‐κB, inhibitor of NF‐κΒ (IκΒ), and IκΒ kinase complex (IKK). IKK …

The inflammatory response is of major importance in host defence, but is involved in all
acute and chronic diseases. Multiple inflammatory cells and molecules are involved. Among …

Fbxw7α is a member of the F-box family of proteins, which function as the substrate-targeting
subunits of SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complexes. Using differential …

Pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, has a
major role in the induction of genes involved in drug transport and metabolism. Recent …