Despite major improvements in outcome over the past decades, acute myeloid leukemia
(AML) remains a life-threatening malignancy in children, with current survival rates of∼ …

Acute lymphoblastic leukaemia (ALL) occurs at all ages but is the most common cancer of
childhood. The current treatment of paediatric ALL is highly successful with up to 90 …

Acute myeloid leukemia is a heterogeneous disease that accounts for approximately 20% of
acute leukemias in children and adolescents. Despite the lack of targeted therapy for most …

Although acute myeloid leukaemia (AML) has long been recognized for its morphological
and cytogenetic heterogeneity, recent high‐resolution genomic profiling has demonstrated a …

ETV6 (TEL) rearrangements are favorable in pediatric acute lymphoblastic leukemia but are
less well characterized in myeloid malignancies. We investigated 9,550 patients with …

Background The biology of acute myeloid leukemia (AML) is complex and includes both
genetic and epigenetic aberrations. We addressed the combined consequences of promoter …

Fanconi anaemia (FA) is an inherited disease with congenital and developmental
abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone …

The aims of this report are to asses the present status of conventional (mor-phological and
cytochemical) methods in diagnosing acute leukemias (AL), to mention additional …

Diagnostic cytogenetic and molecular analysis is recognized as the most valuable
prognostic factor in acute myeloid leukemia (AML). Among 2516 consecutive Chinese …

Mixed lineage leukemia (MLL) fusion genes arise from chromosomal translocations and
induce acute myeloid leukemia through a mechanism involving transcriptional deregulation …