Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …

OBJECTIVE: To review and summarize the current understanding of the epigenetic status of
human sperm in regards to protamination, specific localization and modifications of retained …

CTCF is a ubiquitously expressed regulator of fundamental genomic processes including
transcription, intra-and interchromosomal interactions, and chromatin structure. Because of …

DNA methylation has been comprehensively profiled in normal and cancer cells, but the
dynamics that form, maintain and reprogram differentially methylated regions remain …

Bisulfite treatment of DNA followed by high-throughput sequencing (Bisulfite-seq) is an
important method for studying DNA methylation and epigenetic gene regulation, yet current …

In this Perspective, we synthesize past and present observations in the field of epigenetics to
propose a model in which the epigenome can modulate cellular plasticity in development …

Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive …

De novo DNA methylation is an essential aspect of the epigenetic reprogramming that takes
place during early development, yet factors responsible for its instatement at particular …

The investigation of stress responses has been a focus of plant research, breeding and
biotechnology for a long time. Insight into stress perception, signaling and genetic …

Both the early environment and genetic variation may affect DNA methylation, which is one
of the major molecular marks of the epigenome. The combined effect of these factors on a …