Knee osteoarthritis remains a tremendous public health concern, both in terms of health‐
related quality of life and financial burden of disease. Translational research is a critical step …

Purpose Pain from osteoarthritis (OA) is generally classified as nociceptive (inflammatory).
Animal models of knee OA have shown that sensory nerve fibers innervating the knee are …

Joint degeneration observed in the rat monoiodoacetate (MIA) model of osteoarthritis shares
many histological features with the clinical condition. The accompanying pain phenotype …

Effective treatments for patients suffering from chronic pain remain an area of intense focus
within the pharmaceutical industry, as the development of novel therapies would help to …

Osteoarthritis (OA) is a chronic condition characterized by pain during joint movement.
Additionally, patients with advanced disease experience pain at rest (ie, ongoing pain) that …

Background Recent data have suggested a relationship between acute arthritic pain and
acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The …

Introduction A subgroup of voltage gated sodium channels including Nav1. 8 are exclusively
expressed on small diameter primary afferent neurons and are therefore believed to be …

Murine models of osteoarthritis (OA) provide a potentially powerful tool to elucidate
mechanisms responsible for OA pain. However, few studies have examined pain behaviours …

Background: It was recently reported that the mono-iodoacetate (MIA) experimental model of
osteoarthritis (OA) courses with changes of neurons innervating the affected joints that are …

Introduction Osteoarthritis (OA) results in pain and disability; however, preclinical OA models
often focus on joint-level changes. Gait analysis is one method used to evaluate both …