Developing mRNA-vaccine technologies
T Schlake, A Thess, M Fotin-Mleczek, KJ Kallen - RNA biology, 2012 - Taylor & Francis
mRNA vaccines combine desirable immunological properties with an outstanding safety
profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression …
profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression …
Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion
S Jensen, AR Thomsen - Journal of virology, 2012 - Am Soc Microbiol
Our knowledge regarding the contribution of the innate immune system in recognizing and
subsequently initiating a host response to an invasion of RNA virus has been rapidly …
subsequently initiating a host response to an invasion of RNA virus has been rapidly …
[HTML][HTML] DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE)
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
is implicated in geographic atrophy (GA), an advanced form of age-related macular …
Mitochondrial control of cellular life, stress, and death
L Galluzzi, O Kepp, C Trojel-Hansen… - Circulation …, 2012 - Am Heart Assoc
Since the discovery that mitochondrial membrane permeabilization represents a critical step
in the regulation of intrinsic apoptosis, mitochondria have been viewed as pluripotent …
in the regulation of intrinsic apoptosis, mitochondria have been viewed as pluripotent …
Ubiquitination in signaling to and activation of IKK
ZJ Chen - Immunological reviews, 2012 - Wiley Online Library
A role for polyubiquitination in the activation of inhibitor of NF‐κB (IκB) kinase (IKK) through
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
[HTML][HTML] Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity
K Onomoto, M Jogi, JS Yoo, R Narita, S Morimoto… - 2012 - journals.plos.org
Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors
for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has …
for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has …
[HTML][HTML] Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response
X Jiang, LN Kinch, CA Brautigam, X Chen, F Du… - Immunity, 2012 - cell.com
Summary RIG-I and MDA5 detect viral RNA in the cytoplasm and activate signaling
cascades leading to the production of type-I interferons. RIG-I is activated through sequential …
cascades leading to the production of type-I interferons. RIG-I is activated through sequential …
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo
Y Jin, SA Birlea, PR Fain, TM Ferrara, S Ben… - Nature …, 2012 - nature.com
We previously reported a genome-wide association study (GWAS) identifying 14
susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals …
susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals …
Administration, distribution, metabolism and elimination of polymer therapeutics
E Markovsky, H Baabur-Cohen, A Eldar-Boock… - Journal of controlled …, 2012 - Elsevier
Polymer conjugation is an efficient approach to improve the delivery of drugs and biological
agents, both by protecting the body from the drug (by improving biodistribution and reducing …
agents, both by protecting the body from the drug (by improving biodistribution and reducing …