One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Mycobacterium tuberculosis is an old enemy of the human race, with evidence of infection
observed as early as 5000 years ago. Although more host-restricted than Mycobacterium …

Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective
treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following …

Mycobacterium tuberculosis–macrophage interactions are key to pathogenesis and
clearance of these bacteria. Although interactions between M. tuberculosis-associated lipids …

Trehalose 6, 6′-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an
important regulator of immune responses during Mtb infections. Macrophages recognize …

Rationale: Tuberculosis kills more than 1.5 million people per year, and standard treatment
has remained unchanged for more than 30 years. Tuberculosis (TB) drives matrix …

Lipid droplets (LDs) are highly dynamic cell organelles involved in energy homeostasis and
membrane trafficking. Here, we review how select pathogens interact with LDs. Several RNA …

Background Tuberculosis (TB), a bacterial infection caused by Mycobacterium tuberculosis
(Mtb) remains a significant health problem worldwide with a third of the world population …

The granuloma in tuberculosis (TB), referred to as the tubercle, is a lesion containing
multiple cell types and is the one definite hallmark of this disease. A number of tubercle …

Metabolism is a widely recognized facet of all host–pathogen interactions. Knowledge of its
roles in pathogenesis, however, remains comparatively incomplete. Existing studies have …