Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

Abstract Loss of calcium (Ca2+) homeostasis contributes through different mechanisms to
cell death occurring during the first minutes of reperfusion. One of them is an unregulated …

It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Vascular remodeling and endothelial dysfunction are important pathogenic features of
pulmonary arterial hypertension (PAH). There is a growing body of evidence that …

We tested whether the activation of proteolytic enzymes, calpain, and matrix
metalloproteinases (MMPs) during ischemia–reperfusion (I/R) is mediated through oxidative …

Aims Junctin and triadin are calsequestrin-binding proteins that regulate sarcoplasmic
reticulum (SR) Ca2+ release by interacting with the ryanodine receptor. The levels of these …

Авторы обзора проанализировали современные данные о патогенезе ишемических-
реперфузионных повреждений миокарда. Рассмотрены пути клеточной гибели …

Although heart disease is the primary cause of death in several industrialized nations, there
are no widely-used therapies targeting the ischemic heart muscle; current therapies focus on …

Previous studies have shown that ischemia-reperfusion (I/R) injury is associated with
cardiac dysfunction and depression in sarcolemmal Na+-K+-ATPase activity. This study was …

We performed two different research studies; the first investigation examined the termination
mechanism (s) of calcium induced calcium release and the role of calsequestrin in these …