Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …

The field of microfluidics or lab-on-a-chip technology aims to improve and extend the
possibilities of bioassays, cell biology and biomedical research based on the idea of …

Background There is overwhelming evidence that in vitro three-dimensional tumor cell
cultures more accurately reflect the complex in vivo microenvironment than simple two …

Strained ruthenium (Ru) complexes have been synthesized and characterized as novel
agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible …

Introduction: For the past 30 years 2D-cell-based assay models have dominated preclinical
cancer drug discovery efforts. 2D-cell-based models fail to predict in vivo efficacy …

Clinically relevant in vitro methods are needed to identify new cancer drugs for solid tumors.
We report on a new 3-D spheroid cell culture system aimed to mimic the properties of solid …

In comparison to monolayer cells, MCTS has been claimed as more suitable candidate for
studying drug penetration due to the high resemblance to solid tumors. However, the …

Background Cancer stem cells (CSCs) play an important role in tumor initiation, progression,
and metastasis and are responsible for high therapeutic failure rates. Identification and …

We previously reported the development of a simple, user‐friendly, and versatile 384
hanging drop array plate for 3D spheroid culture and the importance of utilizing 3D cellular …

Background The multicellular tumor spheroid (MCTS) is an in vitro model associating
malignant-cell microenvironment and 3D organization as currently observed in avascular …