Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ
orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often …

Lifelong persistent infection by herpesviruses depends on the balance between host
immune responses and viral immune evasion. CD4 T cells responding to antigens …

Herpes simplex virus type 1 (HSV-1) not only causes painful recurrent oral-labial infections,
it can also cause permanent brain damage and blindness. There is currently no HSV-1 …

The high prevalence and poor prognosis of breast cancer provides a strong rationale for
developing new treatment strategies and preventive and therapeutic agents. Oncolytic …

Conditionally replicating herpes simplex viruses Type 1 (HSV-1) are promising therapeutic
agents for glioma. They can replicate in situ, spread and exhibit oncolytic activity via a direct …

ABSTRACT B virus of the family Herpesviridae is endemic to rhesus macaques but results in
80% fatality in untreated humans who are zoonotically infected. Downregulation of major …

Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from
encephalitis to hematologic malignancies. As evidence emerges about the role of innate …

Viral infection is a major cause of morbidity and mortality, and there are few therapeutic
options available to augment a virus-specific T cell response. Although allo-HLA cross …

C h ap te r 1 man population, which in its turn cause diflerences in the ability of humans to
activate their immune system upon infection or outgrowth of tumors. MHC-I molecules are …

One of the major areas of focus for glioma researchers is the creation of pre-clinical models
that mimic human glioblastomas as precisely as possible. Accurate models of glioblastomas …