Tardive dyskinesia is caused by maladaptive synaptic plasticity: a hypothesis
It has been 50 years since the first patients with tardive dyskinesia (TD) were described, but
the pathophysiology is only partially understood and effective treatments have remained …
the pathophysiology is only partially understood and effective treatments have remained …
Minocycline benefits negative symptoms in early schizophrenia: a randomised double-blind placebo-controlled clinical trial in patients on standard treatment
The onset and early course of schizophrenia is associated with subtle loss of grey matter
which may be responsible for the evolution and persistence of symptoms such as apathy …
which may be responsible for the evolution and persistence of symptoms such as apathy …
Targeting glutamate system for novel antipsychotic approaches: relevance for residual psychotic symptoms and treatment resistant schizophrenia
A De Bartolomeis, C Sarappa, S Magara… - European journal of …, 2012 - Elsevier
Antipsychotics are the mainstay of schizophrenia treatment. However, approximately one
third of schizophrenic patients do not respond or respond poorly to antipsychotics …
third of schizophrenic patients do not respond or respond poorly to antipsychotics …
Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: effects on locomotor activity and GABA signaling in the rat suggest independent …
AJ Hickey, JN Reynolds, RJ Beninger - Pharmacology Biochemistry and …, 2012 - Elsevier
Animal models of schizophrenia symptoms include administration of noncompetitive N-
methyl-d-aspartate (NMDA) glutamate receptor antagonists, such as MK-801, and post …
methyl-d-aspartate (NMDA) glutamate receptor antagonists, such as MK-801, and post …
Movement abnormalities and psychotic-like experiences in childhood: markers of developing schizophrenia?
D MacManus, KR Laurens, EF Walker… - Psychological …, 2012 - cambridge.org
BackgroundBoth involuntary dyskinetic movements and psychotic-like experiences (PLEs)
are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic …
are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic …
[HTML][HTML] Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of …
KR Nations, R Bursi, P Dogterom, L Ereshefsky… - Drugs in R&D, 2012 - Springer
Background A key challenge to dose selection in early central nervous system (CNS) clinical
drug development is that patient tolerability profiles often differ from those of healthy …
drug development is that patient tolerability profiles often differ from those of healthy …
[图书][B] Search for the Causes of Schizophrenia: Volume V
WF Gattaz, H Häfner - 2012 - books.google.com
This volume is a compilation of the presentations and discus sions, arranged in a systematic
manner, of the fifth symposium on the Search for the Causes of Schizophrenia, held in …
manner, of the fifth symposium on the Search for the Causes of Schizophrenia, held in …
Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function
GE Duncan, BH Koller, SS Moy - Brain research, 2012 - Elsevier
The pathophysiology of schizophrenia may involve reduced NMDA receptor function.
Accordingly, experimental models of NMDA receptor hypofunction may be useful for testing …
Accordingly, experimental models of NMDA receptor hypofunction may be useful for testing …
[PDF][PDF] Maximum Tolerated Dose Evaluation of the AMPA Modulator Org 26576 in Healthy Volunteers and Depressed Patients
KR Nations, R Bursi, P Dogterom, L Ereshefsky… - researchgate.net
Background: A key challenge to dose selection in early central nervous system (CNS)
clinical drug development is that patient tolerability profiles often differ from those of healthy …
clinical drug development is that patient tolerability profiles often differ from those of healthy …
Schizophrenia and related disorders
PWJE Kraus - Core Psychiatry E-Book, 2012 - books.google.com
Schizophrenia is probably the single most important cause of chronic psychiatric disability.
Fully half the beds in Europe's psychiatric hospitals are occupied by those afflicted with it …
Fully half the beds in Europe's psychiatric hospitals are occupied by those afflicted with it …