Tumorigenesis is a complex multistep process involving not only genetic and epigenetic
changes in the tumor cell but also selective supportive conditions of the deregulated tumor …

Multiple myeloma (MM) cells are characterized by high protein synthesis resulting in chronic
endoplasmic reticulum (ER) stress, which is adaptively managed by the unfolded protein …

Multiple myeloma (MM) is an incurable B-lymphocyte malignancy. New therapeutic options
have become available during the past several years; however nearly all patients acquire …

Multiple myeloma (MM) is a plasma cell dyscrasia characterized by the presence of multiple
myelomatous “omas” throughout the skeleton, indicating that there is continuous trafficking …

Interactions within the hematopoietic niche in the BM microenvironment are essential for
maintenance of the stem cell pool. In addition, this niche is thought to serve as a sanctuary …

Overexpression of growth differentiation factor 15 (GDF15) by bone marrow mesenchymal
stem cells occurs widely in patients with multiple myeloma, but the pathophysiologic effects …

Multiple myeloma (MM) is a clonal plasma cell disorder frequently accompanied by
hematopoietic impairment. We show that hematopoietic stem and progenitor cells (HSPCs) …

Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells that are
predominantly localized in the bone marrow (BM). Mesenchymal stromal cells (MSCs) give …

BM stromal cells (BMSCs) are key players in the microenvironmental support of multiple
myeloma (MM) cell growth and bone destruction. A spliced form of the X-box–binding …

DNA methylation is one of the heritable epigenetic modifications, leading to repressed gene
expressions and consequent phenotypic alterations without changing the DNA sequence …