Manganese superoxide dismutase: beyond life and death

AK Holley, SK Dhar, Y Xu, DK St. Clair - Amino acids, 2012 - Springer
Manganese superoxide dismutase (MnSOD) is a nuclear-encoded antioxidant enzyme that
localizes to the mitochondria. Expression of MnSOD is essential for the survival of aerobic …

Mitochondria-targeted superoxide dismutase (SOD2) regulates radiation resistance and radiation stress response in HeLa cells

A Hosoki, SI Yonekura, QL Zhao, ZL Wei… - Journal of radiation …, 2012 - jstage.jst.go.jp
Reactive oxygen species (ROS) act as a mediator of ionizing radiation-induced cellular
damage. Previous studies have indicated that MnSOD (SOD2) plays a critical role in …

[HTML][HTML] Manganese superoxide dismutase: a regulator of T cell activation-induced oxidative signaling and cell death

MM Kamiński, D Röth, S Sass, SW Sauer… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Mitochondrial reactive oxygen species (ROS) are indispensible for T cell activation-induced
expression of interleukin 2 (IL-2) and CD95 ligand (CD95L, FasL/Apo-1L) genes, and in …

Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment

M Roh, R van der Meer… - Journal of cellular …, 2012 - Wiley Online Library
Polyploidy has been linked to tumorigenicity mainly due to the chromosomal aberrations.
Elevated reactive oxygen species (ROS) generation, on the other hand, has also been …

Mimic of manganese superoxide dismutase to induce apoptosis of human non-Hodgkin lymphoma Raji cells through mitochondrial pathways

YH Wang, XL Yang, X Han, LF Zhang, HL Li - International …, 2012 - Elsevier
Increased reactive oxygen species (ROS) such as superoxide have been implicated as
causal elements of oncogenesis. A variety of cancers have displayed changes in steady …

Regulation of mitochondrial fates and cellular metabolism via parkin-mediated mitophagy and interaction between apoptosis and autophagy pathways in cancer

S Wang - 2012 - search.proquest.com
Apoptosis is a cell death pathway that regulates tissue homeostasis, and is often altered in
oncogenesis. Autophagy is a lysosome degradation pathway that mediates cellular …

[PDF][PDF] MnSOD promotes tumor invasion via upregulation of FoxM1-MMP2 axis and

PM Chen, YH Wu, MC Li, YW Cheng, CY Chen, H Lee - scholar.archive.org
1Institute of Medical and Molecular Toxicology, 2Institute of Medicine, Chung Shan Medical
University, Taichung, Taiwan, ROC; 3Department of Medical Research, Chung Shan …