Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
M Saitou, S Kagiwada, K Kurimoto - Development, 2012 - journals.biologists.com
Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …
Epigenetic drug discovery: targeting DNA methyltransferases
JM Foulks, KM Parnell, RN Nix… - Journal of …, 2012 - journals.sagepub.com
Epigenetic modification of DNA leads to changes in gene expression. DNA
methyltransferases (DNMTs) comprise a family of nuclear enzymes that catalyze the …
methyltransferases (DNMTs) comprise a family of nuclear enzymes that catalyze the …
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
JE Squires, HR Patel, M Nousch, T Sibbritt… - Nucleic acids …, 2012 - academic.oup.com
The modified base 5-methylcytosine (m 5 C) is well studied in DNA, but investigations of its
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
prevalence in cellular RNA have been largely confined to tRNA and rRNA. In animals, the …
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
F Tuorto, R Liebers, T Musch, M Schaefer… - Nature structural & …, 2012 - nature.com
The function of cytosine-C5 methylation, a widespread modification of tRNAs, has remained
obscure, particularly in mammals. We have now developed a mouse strain defective in …
obscure, particularly in mammals. We have now developed a mouse strain defective in …
[HTML][HTML] The birth of the Epitranscriptome: deciphering the function of RNA modifications
Recent studies have found methyl-6-adenosine in thousands of mammalian genes, and this
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
modification is most pronounced near the beginning of the 3'UTR. We present a perspective …
Reprogramming mammalian somatic cells
Somatic cell nuclear transfer (SCNT), the technique commonly known as cloning, permits
transformation of a somatic cell into an undifferentiated zygote with the potential to develop …
transformation of a somatic cell into an undifferentiated zygote with the potential to develop …
Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome
SI Khan, P Aumsuwan, IA Khan… - Chemical research in …, 2012 - ACS Publications
Aberrant epigenetic alterations in the genome such as DNA methylation and chromatin
remodeling play a significant role in breast cancer development. Since epigenetic …
remodeling play a significant role in breast cancer development. Since epigenetic …
Epigenetics in social insects: a new direction for understanding the evolution of castes
Epigenetic modifications to DNA, such as DNA methylation, can expand a genome's
regulatory flexibility, and thus may contribute to the evolution of phenotypic plasticity. Recent …
regulatory flexibility, and thus may contribute to the evolution of phenotypic plasticity. Recent …
Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins
AM O'Doherty, LC O'Shea, T Fair - Biology of reproduction, 2012 - academic.oup.com
A subset of genes, known as imprinted genes, is present in the mammalian genome.
Genomic imprinting governs the monoallelic expression of these genes, depending on …
Genomic imprinting governs the monoallelic expression of these genes, depending on …
[HTML][HTML] Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis
Background DNA methylation plays an essential role in regulating gene expression under a
variety of conditions and it has therefore been hypothesized to underlie the transitions …
variety of conditions and it has therefore been hypothesized to underlie the transitions …