Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Over 50% of all human cancers lose p53 function. To evaluate the role of aggregation in
cancer, we asked whether wild-type (WT) p53 and the hot-spot mutant R248Q could …

Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite
significant advances, it currently still remains one of the most difficult childhood cancers to …

Mortalin binds to p53 tumor suppressor protein and sequesters it in the cytoplasm. This
results in an inhibition of the transcriptional activation and control of centrosome duplication …

Resistance to cisplatin (CDDP)-based therapy is a major hurdle to the successful treatment
of human ovarian cancer (OVCA), and the chemoresistant phenotype in OVCA cells is …

The karyopherin (KPNA) protein family is involved in nucleocytoplasmic trafficking.
Increased KPNA levels have been found to predict poor prognosis for a variety of solid …

While it is known that cytoplasmic retention of p53 occurs in many solid tumors, the
mechanisms responsible for this retention have not been positively identified. Since …

The p53 tumor suppressor gene (TP53) is the most frequently altered gene in human
cancer. Mutation of the gene has been shown to be an important mechanism of p53 pathway …

Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor
in the pathogenesis of commonly occurring equine sarcoid tumours. Whilst treatment of …

Telomerase, a ribonucleoprotein complex mainly composed of the reverse transcriptase
catalytic subunit (human telomerase reverse transcriptase, hTERT) and the RNA component …