Successful ageing is determined in part by genetic background, but also by experiential
factors associated with lifestyle and culture. Dietary, behavioural and pharmacological …

Age‐related memory loss is considered to commence at middle‐age and coincides with
reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical …

This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
Healthy aged individuals are more likely to suffer profound memory impairments following a …

To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in
postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic …

Exercise has been shown to positively augment adult hippocampal neurogenesis; however,
the cellular and molecular pathways mediating this effect remain largely unknown. Previous …

Aging is associated with low-grade neuroinflammation including primed microglia that may
contribute to deficits in neural plasticity and cognitive function. The current study evaluated …

Acute neuroinflammation reduces adult hippocampal neurogenesis but the role of chronic
neuroinflammation, which may be more representative of ongoing processes in CNS …

Healthy aging and prevention efforts for the elderly warrant attention in a world where the
average mortality rate continues to increase. The current literature review is an overview of …

Future Neurol.(2012) 7 (6) 2 future science group microglia. From this point on, they used
the FACS technique to detect and sort GFP-positive cells (microglia) from other cell types in …

The hippocampus is critical for learning and memory and heavily affected in dementia. The
presence of stem cells in this structure has led to an increased interest in the phenomenon …