Lymphoblastoid cell lines in pharmacogenomic discovery and clinical translation
HE Wheeler, ME Dolan - Pharmacogenomics, 2012 - Future Medicine
The ability to predict how an individual patient will respond to a particular treatment is the
ambitious goal of personalized medicine. The genetic make up of an individual has been …
ambitious goal of personalized medicine. The genetic make up of an individual has been …
Meta-analysis identifies common variants associated with body mass index in east Asians
Multiple genetic loci associated with obesity or body mass index (BMI) have been identified
through genome-wide association studies conducted predominantly in populations of …
through genome-wide association studies conducted predominantly in populations of …
Bioinformatics and variability in drug response: a protein structural perspective
JL Lahti, GW Tang, E Capriotti… - Journal of The …, 2012 - royalsocietypublishing.org
Marketed drugs frequently perform worse in clinical practice than in the clinical trials on
which their approval is based. Many therapeutic compounds are ineffective for a large …
which their approval is based. Many therapeutic compounds are ineffective for a large …
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma
Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide.
Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk …
Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk …
GWASdb: a database for human genetic variants identified by genome-wide association studies
Recent advances in genome-wide association studies (GWAS) have enabled us to identify
thousands of genetic variants (GVs) that are associated with human diseases. As next …
thousands of genetic variants (GVs) that are associated with human diseases. As next …
SNPnexus: a web server for functional annotation of novel and publicly known genetic variants (2012 update)
AZ Dayem Ullah, NR Lemoine… - Nucleic acids …, 2012 - academic.oup.com
Broader functional annotation of single nucleotide variations is a valuable mean for
prioritizing targets in further disease studies and large-scale genotyping projects. We …
prioritizing targets in further disease studies and large-scale genotyping projects. We …
[PDF][PDF] Imputation of exome sequence variants into population-based samples and blood-cell-trait-associated loci in African Americans: NHLBI GO Exome Sequencing …
Researchers have successfully applied exome sequencing to discover causal variants in
selected individuals with familial, highly penetrant disorders. We demonstrate the utility of …
selected individuals with familial, highly penetrant disorders. We demonstrate the utility of …
seeQTL: a searchable database for human eQTLs
seeQTL is a comprehensive and versatile eQTL database, including various eQTL studies
and a meta-analysis of HapMap eQTL information. The database presents eQTL association …
and a meta-analysis of HapMap eQTL information. The database presents eQTL association …
Genome-wide association scan of dental caries in the permanent dentition
Background Over 90% of adults aged 20 years or older with permanent teeth have suffered
from dental caries leading to pain, infection, or even tooth loss. Although caries prevalence …
from dental caries leading to pain, infection, or even tooth loss. Although caries prevalence …
Identification of genes with a correlation between copy number and expression in gastric cancer
L Cheng, P Wang, S Yang, Y Yang, Q Zhang… - BMC medical …, 2012 - Springer
Background To elucidate gene expression associated with copy number changes, we
performed a genome-wide copy number and expression microarray analysis of 25 pairs of …
performed a genome-wide copy number and expression microarray analysis of 25 pairs of …