Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis
H Tanjore, TS Blackwell… - American Journal of …, 2012 - journals.physiology.org
While the factors that regulate the onset and progression of idiopathic pulmonary fibrosis
(IPF) are incompletely understood, recent investigations have revealed that endoplasmic …
(IPF) are incompletely understood, recent investigations have revealed that endoplasmic …
EMT and interstitial lung disease: a mysterious relationship
H Kage, Z Borok - Current opinion in pulmonary medicine, 2012 - journals.lww.com
Advances have been made in elucidating causes and mechanisms of EMT, potentially
leading to new treatment options, although contributions of EMT to lung fibrosis in vivo …
leading to new treatment options, although contributions of EMT to lung fibrosis in vivo …
The pathogenesis of COPD and IPF: distinct horns of the same devil?
New paradigms have been recently proposed in the pathogenesis of both chronic
obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), evidencing …
obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), evidencing …
Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis
A Günther, M Korfei, P Mahavadi… - European …, 2012 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of<
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …
High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C
H Willander, G Askarieh, M Landreh… - Proceedings of the …, 2012 - National Acad Sciences
BRICHOS domains are encoded in> 30 human genes, which are associated with cancer,
neurodegeneration, and interstitial lung disease (ILD). The BRICHOS domain from lung …
neurodegeneration, and interstitial lung disease (ILD). The BRICHOS domain from lung …
Peripheral blood biomarkers in idiopathic pulmonary fibrosis
R Vij, I Noth - Translational Research, 2012 - Elsevier
In this article, we review the evidence for peripheral blood biomarkers in idiopathic
pulmonary fibrosis (IPF), a life-threatening fibrotic lung disease of unknown etiology. We …
pulmonary fibrosis (IPF), a life-threatening fibrotic lung disease of unknown etiology. We …
Activin-A overexpression in the murine lung causes pathology that simulates acute respiratory distress syndrome
E Apostolou, A Stavropoulos… - American journal of …, 2012 - atsjournals.org
Rationale: Activin-A is up-regulated in various respiratory disorders. However, its precise
role in pulmonary pathophysiology has not been adequately substantiated in vivo …
role in pulmonary pathophysiology has not been adequately substantiated in vivo …
The genetic and environmental causes of pulmonary fibrosis
K Macneal, DA Schwartz - Proceedings of the American Thoracic …, 2012 - atsjournals.org
Although substantial progress has been made in understanding the clinical, radiological,
and pathological manifestations of fibrosing interstitial lung diseases (ILD), it remains difficult …
and pathological manifestations of fibrosing interstitial lung diseases (ILD), it remains difficult …
Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by surfactant protein C BRICHOS mutants
JA Maguire, S Mulugeta, MF Beers - … journal of biochemistry & cell biology, 2012 - Elsevier
Epithelial cell dysfunction is now recognized as an important mechanism in the
pathogenesis of interstitial lung diseases. Surfactant Protein C (SP-C), an alveolar type II cell …
pathogenesis of interstitial lung diseases. Surfactant Protein C (SP-C), an alveolar type II cell …
Genetic interstitial lung disease
MS Devine, CK Garcia - Clinics in chest medicine, 2012 - chestmed.theclinics.com
The interstitial lung diseases (ILDs), or diffuse parenchymal lung diseases, are a
heterogeneous collection of more than 100 different pulmonary disorders that affect the …
heterogeneous collection of more than 100 different pulmonary disorders that affect the …