Lentiviral vectors: basic to translational
More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …
delivery. Through continuous improvements these early marker gene-carrying HIVs have …
RNAi-based nanomedicines for targeted personalized therapy
A Daka, D Peer - Advanced drug delivery reviews, 2012 - Elsevier
RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in
order for RNAi to serve as an ideal personalized therapeutics and be clinically approved …
order for RNAi to serve as an ideal personalized therapeutics and be clinically approved …
[HTML][HTML] The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo
Short hairpin RNA (shRNA)-induced RNAi is used for biological discovery and therapeutics.
Dicer, whose normal role is to liberate endogenous miRNAs from their precursors …
Dicer, whose normal role is to liberate endogenous miRNAs from their precursors …
Methods and compositions for enhancing the efficacy and specificity of RNAi
PD Zamore, G Hutvagner, D Schwarz… - US Patent …, 2012 - Google Patents
The present invention provides methods of enhancing the e? icacy and speci? city of RNAi.
The invention also provides compositions for mediating RNAi. In particular, the invention …
The invention also provides compositions for mediating RNAi. In particular, the invention …
Functional parameters of Dicer-independent microRNA biogenesis
Until recently, a Dicer-class RNase III enzyme was believed to be essential for microRNA
(miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this …
(miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this …
Immunoliposomes
E Paszko, MO Senge - Current medicinal chemistry, 2012 - ingentaconnect.com
Since their discovery by Bangham about 50 years ago, liposomes have become promising
tools in drug delivery systems. This has increased the therapeutic index of many drugs, and …
tools in drug delivery systems. This has increased the therapeutic index of many drugs, and …
RNA-interference by single-stranded RNA molecules
US8101348B2 - RNA-interference by single-stranded RNA molecules - Google Patents
US8101348B2 - RNA-interference by single-stranded RNA molecules - Google Patents …
US8101348B2 - RNA-interference by single-stranded RNA molecules - Google Patents …
Method for making a 21 nucleotide double stranded RNA chemically linked at one end
R Kreutzer, S Limmer - US Patent 8,168,776, 2012 - Google Patents
US8168776B2 - Method for making a 21 nucleotide double stranded RNA chemically linked
at one end - Google Patents US8168776B2 - Method for making a 21 nucleotide double …
at one end - Google Patents US8168776B2 - Method for making a 21 nucleotide double …
[HTML][HTML] Distributed computation: the new wave of synthetic biology devices
Synthetic biology (SB) offers a unique opportunity for designing complex molecular circuits
able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable …
able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable …
Method and medicament for inhibiting the expression of a given gene
R Kreutzer, S Limmer - US Patent 8,101,584, 2012 - Google Patents
US8101584B2 - Method and medicament for inhibiting the expression of a given gene -
Google Patents US8101584B2 - Method and medicament for inhibiting the expression of a …
Google Patents US8101584B2 - Method and medicament for inhibiting the expression of a …