Cystic fibrosis: a mucosal immunodeficiency syndrome

TS Cohen, A Prince - Nature medicine, 2012 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

Relevance of new drug discovery to reduce NF-κB activation in cardiovascular disease

R Madonna, R De Caterina - Vascular pharmacology, 2012 - Elsevier
The transcription factor nuclear factor-κB (NF-κB) is a main regulator of the expression of
several genes involved in the activation of inflammation, cell proliferation, cell immunity and …

Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization

C Iosef, TP Alastalo, Y Hou, C Chen… - … of Physiology-Lung …, 2012 - journals.physiology.org
Bronchopulmonary dysplasia (BPD), a chronic lung disease of infancy, is characterized by
arrested alveolar development. Pulmonary angiogenesis, mediated by the vascular …

Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells

SI Lee, KH Park, SJ Kim, YG Kang… - Clinical & …, 2012 - academic.oup.com
Summary Recently, Sirtuin 1 (SIRT1) has been implicated in the molecular control of ageing
and immune response. Although the remodelling of periodontal ligament (PDL) in response …

The suppressive effects of Bursopentine (BP5) on oxidative stress and NF-ĸB activation in lipopolysaccharide-activated murine peritoneal macrophages

D Li, M Xue, Z Geng, P Chen - Cellular Physiology and Biochemistry, 2012 - karger.com
Abstract Background/Aim: Bursopentine (BP5) is a novel thiol-containing pentapeptide
isolated from chicken bursa of Fabricius, and is reported to exert immunomodulatory effects …

Heparin rescues sepsis-associated acute lung injury and lethality through the suppression of inflammatory responses

D Zhao, R Ding, Y Mao, L Wang, Z Zhang, X Ma - Inflammation, 2012 - Springer
Heparin, a potent blood anticoagulant, is known to possess anti-inflammatory activity. In this
work, we investigated whether heparin can ameliorate acute lung injury and lethal response …

Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure

R Yanagisawa, E Warabi, KI Inoue… - The journal of …, 2012 - academic.oup.com
Acute ozone (O3) exposure causes oxidative stress leading inflammation in the lung.
However, its precise mechanisms are not fully elucidated. Here, we examined the role of …

Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease

SP Smeekens, SSV Henriet, MS Gresnigt… - Journal of Interferon & …, 2012 - liebertpub.com
Patients with chronic granulomatous disease (CGD) cannot produce reactive oxygen
species (ROS) due to a genetic defect in the nicotinamide adenine dinucleotide phosphate …

Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock

Y Tanaka, Y Nagai, T Kuroishi, Y Endo… - Journal of leukocyte …, 2012 - academic.oup.com
ABSTRACT Previously, two anti-Ly-6G mAb—RB6-8C5 and 1A8—have been used to
deplete neutrophils in mice and to clarify their involvement in immune responses. During the …

Hematological indices and activity of NTPDase and cholinesterase enzymes in rats exposed to cadmium and treated with N-acetylcysteine

JF Gonçalves, MMMF Duarte, AM Fiorenza… - Biometals, 2012 - Springer
The present study aimed to investigate the influence of N-acetylcysteine (NAC) on cadmium
(Cd) poisoning by evaluating Cd concentration in tissues, hematological indices as well as …