Identification of somatic mutations in parathyroid tumors using whole-exome sequencing
Context: The underlying molecular alterations causing sporadic parathyroid adenomas that
drive primary hyperparathyroidism have not been thoroughly defined. Objective: The aim of …
drive primary hyperparathyroidism have not been thoroughly defined. Objective: The aim of …
[HTML][HTML] Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation
CJ Lips, KM Dreijerink, JW Höppener - Clinics, 2012 - SciELO Brasil
Multiple endocrine neoplasia type 1 is an inherited endocrine tumor syndrome,
predominantly characterized by tumors of the parathyroid glands, gastroenteropancreatic …
predominantly characterized by tumors of the parathyroid glands, gastroenteropancreatic …
[HTML][HTML] Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple …
L Canaff, JF Vanbellinghen, H Kaji, D Goltzman… - Journal of Biological …, 2012 - ASBMB
Multiple endocrine neoplasia type 1 (MEN1) is characterized by tumors of the parathyroid,
enteropancreas, and anterior pituitary. The MEN1 gene encodes the tumor suppressor …
enteropancreas, and anterior pituitary. The MEN1 gene encodes the tumor suppressor …
Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells
Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation
and osteoblast differentiation. In the present study, the differentially expressed genes by …
and osteoblast differentiation. In the present study, the differentially expressed genes by …
Molecular Pathogenesis of Primary Hyperparathyroidism
K Lauter, A Arnold - Handbook of Parathyroid Diseases: A Case-Based …, 2012 - Springer
The molecular pathogenesis of primary hyperparathyroidism has recently been elucidated to
a great extent, but many questions remain. While the molecular genetics of parathyroid …
a great extent, but many questions remain. While the molecular genetics of parathyroid …
[图书][B] The role of menin in regulation of hepatic glucose production through FoxO1
LM Wuescher - 2012 - search.proquest.com
The menin protein is ubiquitously expressed, but mutations causing loss of menin function
lead to a neuro-endocrine specific tumor phenotype called MEN1 Syndrome. Importantly …
lead to a neuro-endocrine specific tumor phenotype called MEN1 Syndrome. Importantly …
NF-κB in Oncogenesis and As a Target for Cancer Therapy
AS Baldwin Jr - Nuclear Factor кB: Regulation and Role in Disease, 2012 - Springer
Given the breadth of biological mechanisms associated with NF-κ B, it is not surprising that
NF-κ B has been discovered to be involved with basic processes in cancer. The roles for NF …
NF-κ B has been discovered to be involved with basic processes in cancer. The roles for NF …