Early determinants of obesity: genetic, epigenetic, and in utero influences
There is an emerging body of work indicating that genes, epigenetics, and the in utero
environment can impact whether or not a child is obese. While certain genes have been …
environment can impact whether or not a child is obese. While certain genes have been …
Induction of osteoarthritis and metabolic inflammation by a very high‐fat diet in mice: effects of short‐term exercise
Objective To test the hypotheses that obesity due to a very high‐fat diet induces knee
osteoarthritis (OA), and that short‐term wheel‐running exercise protects against obesity …
osteoarthritis (OA), and that short‐term wheel‐running exercise protects against obesity …
Isoflavones as a smart curer for non-alcoholic fatty liver disease and pathological adiposity via ChREBP and Wnt signaling
MH Kim, KS Kang - Preventive medicine, 2012 - Elsevier
OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) and pathological adiposity has
emerged as an important modern disease. Along with this, the requirement for alternative …
emerged as an important modern disease. Along with this, the requirement for alternative …
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition
H Mori, TC Prestwich, MA Reid… - The Journal of …, 2012 - Am Soc Clin Investig
Preadipocytes secrete several WNT family proteins that act through autocrine/paracrine
mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by …
mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by …
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
L Guo, X Zhang, D Zhou, AL Okunade, X Su - Journal of lipid research, 2012 - ASBMB
FA 2-hydroxylase (FA2H) is an NAD (P) H-dependent enzyme that initiates FA α oxidation
and is also responsible for the biosynthesis of 2-hydroxy FA (2-OH FA)-containing …
and is also responsible for the biosynthesis of 2-hydroxy FA (2-OH FA)-containing …
Factors predicting nongenetic variability in body weight gain induced by a high‐fat diet in inbred C57BL/6J mice
Inbred C57BL/6J mice displayed large individual variations in weight gain when fed a high‐
fat diet (HFD). The objective of this study was to examine whether this predominantly …
fat diet (HFD). The objective of this study was to examine whether this predominantly …
Inherent plasticity of brown adipogenesis in white fat of mice allows for recovery from effects of post-natal malnutrition
LP Kozak, RA Koza, R Anunciado-Koza, T Mendoza… - PLoS …, 2012 - journals.plos.org
Interscapular brown adipose tissue (iBAT) is formed during fetal development and stable for
the life span of the mouse. In addition, brown adipocytes also appear in white fat depots …
the life span of the mouse. In addition, brown adipocytes also appear in white fat depots …
ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b
Insulin resistance is a risk factor in the development of type 2 diabetes and is a major cause
of atherosclerosis. Reduction in heme oxygenase (HO-1) has been shown to exacerbate …
of atherosclerosis. Reduction in heme oxygenase (HO-1) has been shown to exacerbate …
Targeted inactivation of GPR26 leads to hyperphagia and adiposity by activating AMPK in the hypothalamus
G-protein coupled receptor 26 (GPR26) is a brain-specific orphan GPCR with high
expression in the brain region that controls satiety. Depletion of GPR26 has been shown to …
expression in the brain region that controls satiety. Depletion of GPR26 has been shown to …
Gene expression of mesoderm-specific transcript is upregulated as preadipocytes differentiate to adipocytes in vitro
Y Kadota, M Yanagawa, T Nakaya, T Kawakami… - The journal of …, 2012 - Springer
Mesoderm-specific transcript (Mest) is a distinct gene associated with adipocyte
differentiation and proliferation. The mechanisms regulating expression of the Mest gene are …
differentiation and proliferation. The mechanisms regulating expression of the Mest gene are …