Nucleus accumbens dopamine is known to play a role in motivational processes, and
dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of …

For many years, it has been suggested that drugs that interfere with dopamine (DA)
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …

The decision to eat is strongly influenced by non‐homeostatic factors such as food
palatability. Indeed, the rewarding and motivational value of food can override homeostatic …

Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes.
Rats with impaired DA transmission reallocate their instrumental behavior away from food …

Acute stress can exert beneficial or detrimental effects on different forms of cognition. In the
present study, we assessed the effects of acute restraint stress on different forms of …

Brain dopamine (DA) and adenosine interact in the regulation of behavioral activation and
effort-related processes. In the present studies, a T-maze task was developed in mice for the …

Accumulating evidence indicates integration of dopamine function with metabolic signals,
highlighting a potential role for dopamine in energy balance, frequently construed as …

Decision-making policies are subject to modulation by changing motivational states.
However, so far, little is known about the neurochemical mechanisms that bridge …

We previously showed that mice that selectively and reversibly overexpress striatal D2
receptors (D2R-OE) model the negative symptoms of schizophrenia. Specifically, D2R-OE …

The ability to make adaptive decisions during goal-directed navigation is a fundamental and
highly evolved behavior that requires continual coordination of perceptions, learning and …