Background Mutation of BRAF is a predominant event in cancers with poor prognosis such
as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of …

In recent years, the increasing awareness that somatic mutations and other genetic
aberrations drive human malignancies has led us within reach of personalized cancer …

Background Colon cancer patients with the same stage show diverse clinical behavior dueto
tumor heterogeneity. We aimed to discover distinct classes of tumorsbased on microarray …

Background: BRAF mutations in colorectal cancer (CRC) are disproportionately observed in
tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic …

Peritoneal carcinomatosis (PC) arising from colorectal cancer (CRC) is generally considered
a terminal condition with no treatment options. However novel treatment strategies have …

Our study investigated the impact of specific KRAS mutations and BRAF mutation on
progression‐free survival (PFS) and overall survival (OS) in patients with metastatic …

Background Biological entities do not perform in isolation, and often, it is the nature and
degree of interactions among numerous biological entities which ultimately determines any …

Background Colon cancer patients with the same stage show diverse clinical behavior due
to tumor heterogeneity. We aimed to discover distinct classes of tumors based on microarray …

Background A range of treatments are available for patients with metastatic colorectal
cancer (mCRC). An initial period without active treatment, a 'watch and wait approach', is …

Colorectal cancer (CRC) is one of the most common forms of human cancer worldwide with
approximately 1 million new cases detected every year. CEA is currently the only accepted …