Application of NMR metabolomics to search for human disease biomarkers

T Gebregiworgis, R Powers - Combinatorial chemistry & high …, 2012 - ingentaconnect.com
Since antiquity, humans have used body fluids like saliva, urine and sweat for the diagnosis
of diseases. The amount, color and smell of body fluids are still used in many traditional …

A systems biology approach to nutritional immunology–focus on innate immunity

NJ Afacan, CD Fjell, REW Hancock - Molecular aspects of medicine, 2012 - Elsevier
Innate immunity and nutrient metabolism are complex biological systems that must work in
concert to sustain and preserve life. The effector cells of the innate immune system rely on …

Comparison of the neutrophil proteome in trauma patients and normal controls

L MB Teles, EN Aquino, A CD Neves… - Protein and Peptide …, 2012 - ingentaconnect.com
Background: Neutrophils have an impressive array of microbicidal weapons, and in the
presence of a pathogen, progress from a quiescent state in the bloodstream to a completely …

Finding biomarkers is getting easier

BP Bradley - Ecotoxicology, 2012 - Springer
Single biomarkers are rarely accurate. Even suites of biomarkers can give conflicting results.
Ideally potent combinations of variables are isolated which accurately identify specific …

Proteomic analysis of rat skeletal muscle submitted to one bout of incremental exercise

PG Gandra, RH Valente, J Perales… - … journal of medicine …, 2012 - Wiley Online Library
Exercise can alter gene transcriptional and protein translational rates leading to changes in
protein abundance toward adaptation to exercise. We investigated the alterations in protein …

Operator-and software-related post-experimental variability and source of error in 2-DE analysis

R Millioni, L Puricelli, S Sbrignadello, E Iori, E Murphy… - Amino Acids, 2012 - Springer
In the field of proteomics, several approaches have been developed for separating proteins
and analyzing their differential relative abundance. One of the oldest, yet still widely used, is …

A Bayesian model for classifying all differentially expressed proteins simultaneously in 2D PAGE gels

SH Wu, MA Black, RA North, AG Rodrigo - BMC bioinformatics, 2012 - Springer
Background Two-dimensional polyacrylamide gel electrophoresis (2D PAGE) is commonly
used to identify differentially expressed proteins under two or more experimental or …