Improved supportive care, more precise risk stratification, and personalized chemotherapy
based on the characteristics of leukemic cells and hosts (eg, pharmacokinetics and …

B-precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood tumor and
the leading cause of cancer-related death in children and young adults. The majority of B …

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive
malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP …

Purpose To examine population-based improvements in survival and the impact of clinical
covariates on outcome among children and adolescents with acute lymphoblastic leukemia …

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1 …

We investigated the therapeutic potential of JQ1, an inhibitor of the BET class of human
bromodomain proteins, in B-cell acute lymphoblastic leukemia (B-ALL). We show that JQ1 …

Abstract CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been
identified in Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL), a …

Genomic profiling has transformed our understanding of the genetic basis of acute
lymphoblastic leukemia (ALL). Recent years have seen a shift from microarray analysis and …

As controversy exists regarding the prognostic significance of genomic rearrangements of
CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as …

Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL)
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …