Coenzyme Q 10 (CoQ 10) deficiency has been associated with 5 major clinical phenotypes:
encephalomyopathy, severe infantile multisystemic disease, nephropathy, cerebellar ataxia …

Mitochondrial cytopathies constitute a group of rare diseases that are characterized by their
frequent multisystemic involvement, extreme variability of phenotype and complex genetics …

Cardiovascular benefits of ubiquinone have been previously demonstrated, and we
administered it as a novel therapy in an experimental model of type 2 diabetic nephropathy …

Podocytes are highly specialized epithelial cells that line the urinary surface of the
glomerular capillary tuft. To maintain kidney filtration, podocytes oppose the high …

An ENMC meeting was held in Naarden, the Netherlands (July 9th–11th 2010) with 12
clinical and basic scientists and three industrial representatives from Europe (France …

BACKGROUND: Although causative mutations have been identified for numerous
mitochondrial disorders, few disease-modifying treatments are available. Two examples of …

FSGS is caused by a complex interplay of inherent genetic susceptibilities and external
injurious factors acting on podocytes. Critical levels of podocyte stress eventuate in …

Aims. Proteinuria not only is a sign of kidney damage, but also is involved in the progression
of renal diseases as an independent pathologic factor. Clinically, glomerular proteinuria is …

Riboflavin and ubiquinone (Coenzyme Q 10, CoQ 10) deficiencies are heterogeneous
groups of autosomal recessive conditions affecting both children and adults. Riboflavin …

Coenzyme Q10 (CoQ10) is a potent lipophilic antioxidant in cell membranes and a carrier of
electrons in the mitochondrial respiratory chain. We previously characterized the effects of …