Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …

Szyf M. The early‐life social environment and DNA methylation. DNA methylation is a
chemical modification of DNA that confers, upon identical sequences, different identities that …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Rationale: DNA methylation is an important epigenetic mechanism, which often occurs in
response to environmental stimuli and is crucial in regulating gene expression. It is likely …

The role of DNA sequence in determining chromatin state is incompletely understood. We
have previously demonstrated that large chromosomal segments from human cells …

Many studies have demonstrated that epigenetic mechanisms are important in the
regulation of gene expression during embryogenesis, gametogenesis, and other forms of …

Epigenetic silencing of genes is now recognized to be an important mechanism for
inactivation of tumor suppressor genes in carcinogenesis. Because the role of genetic …

Human 8-oxoguanine DNA glycosylase (OGG1) is a key enzyme involved in removing 7, 8-
dihydro-8-oxoguanine (8-oxoG), a highly mutagenic DNA lesion generated by oxidative …

Gallbladder cancer is an infrequent neoplasia with noticeable geographical variations in its
incidence around the world. In Chile, it is the main cause of death owing to cancer in women …

DNA methylation is a type of epigenetic modification in the human genome, which means
that gene expression is regulated without altering the DNA sequence. Methylation and the …