Aging, dementia, and cancer share a critical set of altered cellular functions in response to
DNA damage, genotoxic stress, and other insults. Recent data suggest that the molecular …

Ginsenoside F2 (F2) was assessed for its antiproliferative activity against breast cancer stem
cells (CSCs). F2 induced apoptosis in breast CSCs by activating the intrinsic apoptotic …

Detection of neuronal cell death is a standard requirement in cell culture models of
neurodegenerative diseases. Although plenty of viability assays are available for in vitro …

MicroRNAs (miRNAs) are short, noncoding RNAs that function as posttranscriptional
regulators of gene expression by controlling translation of mRNAs. A subset of miRNAs may …

Ischemic stroke is caused by a loss of blood flow and deficiency in glucose and oxygen to
the brain. The lack of sufficient glucose and oxygen results in varying degrees of tissue …

We developed an inbred rat model of diabetic embryopathy, in which the offspring displays
skeletal malformations (agnathia or micrognathia) when the mother is diabetic, and no …

Neuronal cell death causes progressive loss of brain tissue and function after acute brain
injury and in chronic neurodegenerative diseases. Although the pathological features of …

Delayed neuronal death in the penumbral region of a stroke is largely responsible for many
negative implications seen in stroke victims. This type of neuronal death occurs in many …

Induced pluripotent stem (iPS) cells can be generated by the expression of pluripotency
factors and oncogenes; however, the efficiency of generating iPS cells is extremely low (less …

This thesis presents the first report of the comprehensive and quantitative analysis of the
effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein …