Targeting fatty acid binding protein (FABP) anandamide transporters–a novel strategy for development of anti-inflammatory and anti-nociceptive drugs
Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been
identified by us as intracellular transporters for the endocannabinoid anandamide (AEA) …
identified by us as intracellular transporters for the endocannabinoid anandamide (AEA) …
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone attenuates postincisional pain by regulating macrophage polarization
M Hasegawa-Moriyama, T Ohnou, K Godai… - Biochemical and …, 2012 - Elsevier
Acute inflammation triggered by macrophage infiltration to injured tissue promotes wound
repair and may induce pain hypersensitivity. Peroxisome proliferator-activated receptor γ …
repair and may induce pain hypersensitivity. Peroxisome proliferator-activated receptor γ …
Increased central and peripheral inflammation and inflammatory hyperalgesia in Zucker rat model of leptin receptor deficiency and genetic obesity
T Iannitti, A Graham, S Dolan - Experimental physiology, 2012 - Wiley Online Library
This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats
using established models of inflammatory pain, and using real‐time PCR, profiled …
using established models of inflammatory pain, and using real‐time PCR, profiled …
Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
S Kaulaskar, P Bhutada, A Rahigude… - Zhong xi yi jie he xue …, 2012 - europepmc.org
Objective To study the analgesic effects of naringenin on chronic constriction injury (CCI)
model of neuropathic pain. Methods After inducing of neuropathic pain by CCI, treatment …
model of neuropathic pain. Methods After inducing of neuropathic pain by CCI, treatment …
Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception
Y Weng, PA Batista-Schepman, ME Barabas… - Molecular …, 2012 - journals.sagepub.com
Background: The Transient Receptor Potential (TRP) ion channel TRPA1 is a key player in
pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N …
pain pathways. Irritant chemicals activate ion channel TRPA1 via covalent modification of N …