Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation, cellular specification and cancer development. Here, we describe an R package …

Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …

Background During the past 5 years, high-throughput technologies have been successfully
used by epidemiology studies, but almost all have focused on sequence variation through …

We have extensively characterized the DNA methylomes of 139 patients with chronic
lymphocytic leukemia (CLL) with mutated or unmutated IGHV and of several mature B-cell …

All cancers harbor molecular alterations in their genomes. The transcriptional consequences
of these somatic mutations have not yet been comprehensively explored in lung cancer …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic
alterations during tumorigenesis including aberrant DNA hypermethylation of tumor …

DNA methylation and nucleosome positioning work together to generate chromatin
structures that regulate gene expression. Nucleosomes are typically mapped using …