Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
FG Goh, KS Midwood - Rheumatology, 2012 - academic.oup.com
RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …
inflammation leading to progressive joint destruction. Recent advances in the molecular …
Current understanding of rheumatoid arthritis therapy
I Colmegna, BR Ohata… - Clinical Pharmacology & …, 2012 - Wiley Online Library
Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis
(RA), together with the availability of new therapies, has changed the way we think about …
(RA), together with the availability of new therapies, has changed the way we think about …
The TIGIT/CD226 axis regulates human T cell function
T cell Ig and ITIM domain (TIGIT) is a newly identified receptor expressed on T cells that
binds to CD155 on the dendritic cell surface, driving them to a more tolerogenic phenotype …
binds to CD155 on the dendritic cell surface, driving them to a more tolerogenic phenotype …
Risk of malignancies in patients with rheumatoid arthritis treated with biologic therapy: a meta-analysis
MA Lopez-Olivo, JH Tayar, JA Martinez-Lopez… - Jama, 2012 - jamanetwork.com
Context Concerns exist regarding the potential development of malignancies in patients with
rheumatoid arthritis (RA) who are receiving biologic response modifiers (BRMs). Objective …
rheumatoid arthritis (RA) who are receiving biologic response modifiers (BRMs). Objective …
Positivity for anti-cyclic citrullinated peptide is associated with a better response to abatacept: data from the 'Orencia and Rheumatoid Arthritis' registry
JE Gottenberg, P Ravaud, A Cantagrel… - Annals of the …, 2012 - ard.bmj.com
Objectives Very limited data are available regarding the efficacy of abatacept (ABA) in real
life. The aims of this study were to determine the efficacy of ABA in rheumatoid arthritis and …
life. The aims of this study were to determine the efficacy of ABA in rheumatoid arthritis and …
MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential …
H Fayyad-Kazan, R Rouas, M Fayyad-Kazan… - Journal of Biological …, 2012 - ASBMB
Regulatory T cells (Tregs) are characterized by a high expression of IL-2 receptor α chain
(CD25) and of forkhead box P3 (FOXP3), the latter being essential for their development and …
(CD25) and of forkhead box P3 (FOXP3), the latter being essential for their development and …
Interleukin-7: a key mediator in T cell-driven autoimmunity, inflammation, and tissue destruction
A Bikker, C Erik Hack, F PJG Lafeber… - Current …, 2012 - ingentaconnect.com
IL-7, expressed by stromal cells in primary lymphoid organs, is known for its critical role in
the development and homeostatic expansion of T cells in humans and mice. IL-7 is equally …
the development and homeostatic expansion of T cells in humans and mice. IL-7 is equally …
Kinase inhibitors: a new class of antirheumatic drugs
VC Kyttaris - Drug design, development and therapy, 2012 - Taylor & Francis
The outlook for patients with rheumatoid arthritis has improved significantly over the last
three decades with the use of disease-modifying antirheumatic drugs. However, despite the …
three decades with the use of disease-modifying antirheumatic drugs. However, despite the …
[HTML][HTML] Preclinical efficacy and immunological safety of FR104, an antagonist anti-CD28 monovalent Fab′ antibody
N Poirier, C Mary, N Dilek, J Hervouet, D Minault… - American Journal of …, 2012 - Elsevier
Antagonist anti-CD28 antibodies prevent T cell costimulation and differentiate from CTLA4Ig
since they cannot block CTLA-4 and PDL-1 coinhibitory signals. They demonstrated efficacy …
since they cannot block CTLA-4 and PDL-1 coinhibitory signals. They demonstrated efficacy …
Belatacept: from rational design to clinical application
T Wekerle, JM Grinyó - Transplant International, 2012 - Wiley Online Library
Gradually improved immunosuppression has contributed significantly to the progress
achieved in transplantation medicine so far. Nevertheless, current drug regimens are …
achieved in transplantation medicine so far. Nevertheless, current drug regimens are …