BACKGROUND: Measurement of biomarkers has been incorporated within clinical research
studies of asthma to characterize the population and associate the disease with …

Exhaled breath contains thousands of volatile organic compounds (VOCs) of which the
composition varies depending on health status. Various metabolic processes within the …

Rationale: Airway eosinophilia is typical of asthma, and many controller treatments target
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …

BACKGROUND: The goals of asthma treatment include preventing recurrent exacerbations.
Yet there is no consensus about the terminology for describing or defining “exacerbation” or …

Background Anti‐leukotrienes (5‐lipoxygenase inhibitors and leukotriene receptors
antagonists) serve as alternative monotherapy to inhaled corticosteroids (ICS) in the …

Patients with severe or difficult-to-treat asthma are an understudied population but account
for considerable asthma morbidity, mortality, and costs. The Epidemiology and Natural …

Rationale: To date, most studies aimed at discovering genetic factors influencing treatment
response in asthma have focused on biologic candidate genes. Genome-wide association …

Background Asthma is a common chronic respiratory disease in children and adults. An
important genetic component to asthma susceptibility has long been recognized, most …

Background International guidelines advocate a standard approach to asthma management
for all, despite its heterogeneity.“Personalized” treatment of inflammatory asthma …

Severe asthma is considered a heterogeneous disease in which a variety of clinical,
physiological and inflammatory markers determine disease severity. Pivotal studies in the …