The chemical complexity of cellular microtubules: tubulin post‐translational modification enzymes and their roles in tuning microtubule functions
CP Garnham, A Roll‐Mecak - Cytoskeleton, 2012 - Wiley Online Library
Cellular microtubules are marked by abundant and evolutionarily conserved post‐
translational modifications that have the potential to tune their functions. This review focuses …
translational modifications that have the potential to tune their functions. This review focuses …
Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders
S Balaratnasingam, A Janca - Pharmacology & therapeutics, 2012 - Elsevier
Brain Derived Neurotrophic Factor (BDNF) is a unique member of the neurotrophin family
with potent and plethoric effects on the proliferation, differentiation, survival and death of …
with potent and plethoric effects on the proliferation, differentiation, survival and death of …
MYST protein acetyltransferase activity requires active site lysine autoacetylation
The MYST protein lysine acetyltransferases are evolutionarily conserved throughout
eukaryotes and acetylate proteins to regulate diverse biological processes including gene …
eukaryotes and acetylate proteins to regulate diverse biological processes including gene …
Epigenomics and interindividual differences in drug response
M Ivanov, M Kacevska… - Clinical Pharmacology …, 2012 - Wiley Online Library
Epigenomics is a rapidly growing field. New developments in epigenetics, such as the
recently described modified cytosine variants (eg, 5‐hydroxymethylcytosine, 5hmC) and an …
recently described modified cytosine variants (eg, 5‐hydroxymethylcytosine, 5hmC) and an …
Epigenetics of neurobiology and behavior during development and adulthood
TL Roth - Developmental psychobiology, 2012 - Wiley Online Library
Gene–environment interactions have long been recognized for their important role in
mediating the development and functions of the central nervous system (CNS). The study of …
mediating the development and functions of the central nervous system (CNS). The study of …
Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates
Alteration of the acetylation state of histone proteins contributes to transcriptional regulation
and epigenetic inheritance. Dysregulation of these processes may lead to human diseases …
and epigenetic inheritance. Dysregulation of these processes may lead to human diseases …
Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria
JM Moore, E Bradshaw, RF Seipke, MI Hutchings… - Methods in …, 2012 - Elsevier
Secondary metabolite production from Streptomyces bacteria is primarily controlled at the
level of transcription. Under normal laboratory conditions, the majority of the biosynthetic …
level of transcription. Under normal laboratory conditions, the majority of the biosynthetic …
Chemical and biochemical approaches in the study of histone methylation and demethylation
KK Li, C Luo, D Wang, H Jiang… - Medicinal research …, 2012 - Wiley Online Library
Histone methylation represents one of the most critical epigenetic events in DNA function
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …
Redox signaling and histone acetylation in acute pancreatitis
J Escobar, J Pereda, G López-Rodas… - Free Radical Biology and …, 2012 - Elsevier
Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines
in the activation phase of inflammation, particularly through mitogen-activated protein …
in the activation phase of inflammation, particularly through mitogen-activated protein …
Epigenetics: concepts and relevance to IBD pathogenesis
M Scarpa, E Stylianou - Inflammatory bowel diseases, 2012 - academic.oup.com
The purpose of this review is to introduce the exciting field of epigenetics and to describe
how it could explain the mechanisms by which environmental changes induce pathological …
how it could explain the mechanisms by which environmental changes induce pathological …