The chemical complexity of cellular microtubules: tubulin post‐translational modification enzymes and their roles in tuning microtubule functions

CP Garnham, A Roll‐Mecak - Cytoskeleton, 2012 - Wiley Online Library
Cellular microtubules are marked by abundant and evolutionarily conserved post‐
translational modifications that have the potential to tune their functions. This review focuses …

Brain derived neurotrophic factor: a novel neurotrophin involved in psychiatric and neurological disorders

S Balaratnasingam, A Janca - Pharmacology & therapeutics, 2012 - Elsevier
Brain Derived Neurotrophic Factor (BDNF) is a unique member of the neurotrophin family
with potent and plethoric effects on the proliferation, differentiation, survival and death of …

MYST protein acetyltransferase activity requires active site lysine autoacetylation

H Yuan, D Rossetto, H Mellert, W Dang… - The EMBO …, 2012 - embopress.org
The MYST protein lysine acetyltransferases are evolutionarily conserved throughout
eukaryotes and acetylate proteins to regulate diverse biological processes including gene …

Epigenomics and interindividual differences in drug response

M Ivanov, M Kacevska… - Clinical Pharmacology …, 2012 - Wiley Online Library
Epigenomics is a rapidly growing field. New developments in epigenetics, such as the
recently described modified cytosine variants (eg, 5‐hydroxymethylcytosine, 5hmC) and an …

Epigenetics of neurobiology and behavior during development and adulthood

TL Roth - Developmental psychobiology, 2012 - Wiley Online Library
Gene–environment interactions have long been recognized for their important role in
mediating the development and functions of the central nervous system (CNS). The study of …

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates

SD Furdas, S Kannan, W Sippl, M Jung - Archiv der Pharmazie, 2012 - Wiley Online Library
Alteration of the acetylation state of histone proteins contributes to transcriptional regulation
and epigenetic inheritance. Dysregulation of these processes may lead to human diseases …

Use and discovery of chemical elicitors that stimulate biosynthetic gene clusters in Streptomyces bacteria

JM Moore, E Bradshaw, RF Seipke, MI Hutchings… - Methods in …, 2012 - Elsevier
Secondary metabolite production from Streptomyces bacteria is primarily controlled at the
level of transcription. Under normal laboratory conditions, the majority of the biosynthetic …

Chemical and biochemical approaches in the study of histone methylation and demethylation

KK Li, C Luo, D Wang, H Jiang… - Medicinal research …, 2012 - Wiley Online Library
Histone methylation represents one of the most critical epigenetic events in DNA function
regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide …

Redox signaling and histone acetylation in acute pancreatitis

J Escobar, J Pereda, G López-Rodas… - Free Radical Biology and …, 2012 - Elsevier
Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines
in the activation phase of inflammation, particularly through mitogen-activated protein …

Epigenetics: concepts and relevance to IBD pathogenesis

M Scarpa, E Stylianou - Inflammatory bowel diseases, 2012 - academic.oup.com
The purpose of this review is to introduce the exciting field of epigenetics and to describe
how it could explain the mechanisms by which environmental changes induce pathological …