Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no
effective treatment is available for AD. Analysis of transgenic mouse models of AD has …

Summary cis-trans isomerization of proteins phosphorylated by proline-directed kinases is
proposed to control numerous signaling molecules and is implicated in the pathogenesis of …

The microtubule-associated protein tau plays a critical role in the pathogenesis of
Alzheimer's disease and several related disorders. In the disease tau aggregates into paired …

Recent data indicate that Tau immunotherapy may be relevant for interfering with
neurofibrillary degeneration in Alzheimer disease and related disorders referred to as …

With populations ageing worldwide, the need for treating and preventing diseases
associated with high age is pertinent. Alzheimer's disease (AD) is reaching epidemic …

The exact mechanisms leading to Alzheimer's disease (AD) are largely unknown, limiting
the identification of effective disease-modifying therapies. The two principal …

Tau is a microtubule-associated protein thought to help modulate the stability of neuronal
microtubules. In tauopathies, including Alzheimer's disease and several frontotemporal …

The abnormal deposition of proteins in and around neurons is a common pathological
feature of many neurodegenerative diseases. Among these pathological proteins, the …

Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mainly the memory
and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau …