α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

It has been suggested that exposure to pesticides might be involved in the etiology of
Parkinson's disease (PD). We conducted an updated systematic review of the epidemiologic …

Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …

The accumulation of misfolded proteins is a fundamental pathogenic process in
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …

Since the discovery and isolation of α-synuclein (α-syn) from human brains, it has been
widely accepted that it exists as an intrinsically disordered monomeric protein. Two recent …

Regulation of amyloid-β (Aβ) precursor protein (APP) expression is complex. MicroRNAs
(miRNAs) are expected to participate in the molecular network that controls this process. The …

α-Synuclein is an abundant presynaptic protein that binds to phospholipids and synaptic
vesicles. Physiologically, α-synuclein functions as a SNARE-protein chaperone that …

The conformational properties of soluble α‐synuclein, the primary protein found in patients
with Parkinson's disease, are thought to play a key role in the structural transition to amyloid …

Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia,
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies …

Abstract α-Synuclein is the major protein associated with Lewy body dementia, Parkinson's
disease and multiple system atrophy. Since α-synuclein is present in the brain in …