Aging is characterized by a deterioration in the maintenance of homeostatic processes over
time, leading to functional decline and increased risk for disease and death. The aging …

Obesity is a condition in which excess or abnormal fat accumulation may present with
adverse effects on health and decreased life expectancy. Increased body weight and …

Rapamycin, an inhibitor of mechanistic target of rapamycin complex 1 (mTORC1), extends
the life spans of yeast, flies, and mice. Calorie restriction, which increases life span and …

Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that
circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major …

Recent discoveries suggest that aging is neither driven by accumulation of molecular
damage of any cause, nor by random damage of any kind. Some predictions of a new …

Insulin-like growth factor 1 (IGF-1) is a pleiotropic polypeptide. Its expression is tightly
regulated and it plays significant roles during early development, maturation, and adulthood …

The links between hormonal signalling and lifespan have been well documented in a range
of model organisms. For example, in C. elegans or D. melanogaster, lifespan can be …

The continuing increase in the prevalence of obesity and metabolic disorders such as type‐II
diabetes and an accelerating aging population globally will remain the major contributors to …

In recent years, novel model systems have made significant contributions to our
understanding of the processes that control the ageing of whole organisms. However, there …

Traditional Yiddish Proverb METABoLIC syndrome consists of metabolic defects associated
with increased risks of type 2 diabetes mellitus, cardiovascular diseases, prothrombotic and …