The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices
The extracellular matrix (ECM) is a complex meshwork of cross-linked proteins providing
both biophysical and biochemical cues that are important regulators of cell proliferation …
both biophysical and biochemical cues that are important regulators of cell proliferation …
Cardiac mitochondrial matrix and respiratory complex protein phosphorylation
R Covian, RS Balaban - American Journal of Physiology …, 2012 - journals.physiology.org
It has become appreciated over the last several years that protein phosphorylation within the
cardiac mitochondrial matrix and respiratory complexes is extensive. Given the importance …
cardiac mitochondrial matrix and respiratory complexes is extensive. Given the importance …
Regulation of protein kinase D1 activity
SF Steinberg - Molecular pharmacology, 2012 - ASPET
Protein kinase D1 (PKD1) is a stress-activated serine/threonine kinase that plays a vital role
in various physiologically important biological processes, including cell growth, apoptosis …
in various physiologically important biological processes, including cell growth, apoptosis …
Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer
K Nacerddine, JB Beaudry, V Ginjala… - The Journal of …, 2012 - Am Soc Clin Investig
Prostate cancer (PCa) is a major lethal malignancy in men, but the molecular events and
their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic …
their interplay underlying prostate carcinogenesis remain poorly understood. Epigenetic …
A strategy for large-scale phosphoproteomics and SRM-based validation of human breast cancer tissue samples
Protein phosphorylation is a key mechanism of cellular signaling pathways and aberrant
phosphorylation has been implicated in a number of human diseases. Thus, approaches in …
phosphorylation has been implicated in a number of human diseases. Thus, approaches in …
In vivo quantitative proteomics: the SILAC mouse
Mass spectrometry-based proteomics is a field that has been quickly developing, enabling
increasingly giving in-depth characterization of the proteomes of cells and tissues. Current …
increasingly giving in-depth characterization of the proteomes of cells and tissues. Current …
Chianina beef tenderness investigated through integrated Omics
A D'Alessandro, C Marrocco, S Rinalducci… - Journal of …, 2012 - Elsevier
In the present study we performed an integrated proteomics, interactomics and
metabolomics analysis of Longissimus dorsi tender and tough meat samples from Chianina …
metabolomics analysis of Longissimus dorsi tender and tough meat samples from Chianina …
Extracellular phosphorylation and phosphorylated proteins: not just curiosities but physiologically important
G Yalak, V Vogel - Science signaling, 2012 - science.org
Mining of the literature and high-throughput mass spectrometry data from both healthy and
diseased tissues and from body fluids reveals evidence that various extracellular proteins …
diseased tissues and from body fluids reveals evidence that various extracellular proteins …
Nestin protein is phosphorylated in adult neural stem/progenitor cells and not endothelial progenitor cells
J Namiki, S Suzuki, T Masuda, Y Ishihama… - Stem cells …, 2012 - Wiley Online Library
An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It
was shown to be required for the survival and self‐renewal of neural stem cells according to …
was shown to be required for the survival and self‐renewal of neural stem cells according to …
[HTML][HTML] Septin 8 is an interaction partner and in vitro substrate of MK5
A Shiryaev, S Kostenko, G Dumitriu… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To identify novel substrates for the mitogen-activated protein kinase-activated protein
kinase 5 (MK5). METHODS: Yeast two-hybrid screening with MK5 as bait was used to …
kinase 5 (MK5). METHODS: Yeast two-hybrid screening with MK5 as bait was used to …