Studies using high-resolution genome-wide approaches have recently reported that
genomic and epigenomic alterations frequently accumulate in human pluripotent cells …

Pluripotency manifests during mammalian development through formation of the epiblast,
founder tissue of the embryo proper. Rodent pluripotent stem cells can be considered as two …

Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease
and development, drug discovery, and regenerative medicine. However, it is important to …

Although distinct human induced pluripotent stem cell (hiPSC) lines can display
considerable epigenetic variation, it has been unclear whether such variability impacts their …

Although human induced pluripotent stem cells (hiPSCs) have enormous potential in
regenerative medicine, their epigenetic variability suggests that some lines may not be …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a leading monogenic
neurodegenerative disorder affecting premutation carriers of the fragile X (FMR1) gene. To …

The different pluripotent states of mouse embryonic stem cells (ESCs) in vitro have been
shown to correspond to stages of mouse embryonic development,,,,,. For human cells, little …

Female human induced pluripotent stem cell (hiPSC) lines exhibit variability in X-inactivation
status. The majority of hiPSC lines maintain one transcriptionally active X (Xa) and one …

The nonvillous parts of the placenta include the chorionic plate, cell islands, cell columns,
and the extravillous trophoblast derived from them that invades the endometrium and …

X chromosome inactivation (XCI) is a striking example of developmentally regulated, wide‐
range heterochromatin formation that is initiated during early embryonic development. XCI is …