The uterus is an essential organ for reproduction in mammals that derives from the Müllerian
duct. Despite the importance of the uterus for the fertility and health of women and their …

When amniotes appeared during evolution, embryos freed themselves from intracellular
nutrition; development slowed, the mid-blastula transition was lost and maternal …

Gonadal sex determination in vertebrates generally follows a sequence of genetically
programmed events. In what is seemingly becoming a pattern, all confirmed or current …

Background Despite the popularity of zebrafish as a research model, its sex determination
(SD) mechanism is still unknown. Most cytogenetic studies failed to find dimorphic sex …

The presence of germ cells in the early gonad is important for sexual fate determination and
gonadal development in vertebrates. Recent studies in zebrafish and medaka have shown …

In mammals, male sex determination is governed by SRY-dependent activation of Sox9,
whereas female development involves R-spondin1 (RSPO1), an activator of the WNT/beta …

In vertebrates, the gonad arises as a bipotential primordium that can differentiate as a testis
or ovary. Cells are initially primed to adopt either fate by balanced antagonistic signaling …

Differential gene expression regulates tissue morphogenesis. The embryonic gonad is a
good example, where the developmental decision to become an ovary or testis is governed …

Embryonic and fetal sexual development is often described as sexual determination and
differentiation. The sexual determination of an individual animal's gender occurs as the …

The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of
the gonad, male or female, is determined by a population of somatic cells that differentiate …