Epigenetics and the environment: emerging patterns and implications
R Feil, MF Fraga - Nature reviews genetics, 2012 - nature.com
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …
chromatin modifications. There has been considerable interest in whether environmental …
[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
OS Anderson, KE Sant, DC Dolinoy - The Journal of nutritional …, 2012 - Elsevier
DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …
Distinct DNA methylomes of newborns and centenarians
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
DNA methylation profiling in the clinic: applications and challenges
H Heyn, M Esteller - Nature Reviews Genetics, 2012 - nature.com
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …
development of genome-wide techniques for their identification. The ever-growing number …
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …
longevity, yet the causes and functional consequences of these variants remain unclear. To …
Understanding transgenerational epigenetic inheritance via the gametes in mammals
L Daxinger, E Whitelaw - Nature Reviews Genetics, 2012 - nature.com
It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …
information—can be inherited from the parent to the offspring. However, many questions …
The intergenerational transmission of risk and trust attitudes
Recent theories endogenize the attitude endowments of individuals, assuming that they are
shaped by the attitudes of parents and other role models. This paper tests empirically for the …
shaped by the attitudes of parents and other role models. This paper tests empirically for the …
Plasticity and robustness in development and evolution
P Bateson, P Gluckman - International Journal of Epidemiology, 2012 - academic.oup.com
Biology presents many wonders, but one of the most remarkable is how a complex
multicellular organism grows from a single cell. Until recently, the processes involved …
multicellular organism grows from a single cell. Until recently, the processes involved …
The role of DNA methylation in aging, rejuvenation, and age-related disease
AA Johnson, K Akman, SRG Calimport… - Rejuvenation …, 2012 - liebertpub.com
DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …
organisms. Gene silencing through methylation occurs through the activity of DNA …