Epigenetics and the environment: emerging patterns and implications

R Feil, MF Fraga - Nature reviews genetics, 2012 - nature.com
Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role

KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

OS Anderson, KE Sant, DC Dolinoy - The Journal of nutritional …, 2012 - Elsevier
DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

Distinct DNA methylomes of newborns and centenarians

H Heyn, N Li, HJ Ferreira, S Moran… - Proceedings of the …, 2012 - National Acad Sciences
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …

DNA methylation profiling in the clinic: applications and challenges

H Heyn, M Esteller - Nature Reviews Genetics, 2012 - nature.com
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population

JT Bell, PC Tsai, TP Yang, R Pidsley, J Nisbet… - PLoS …, 2012 - journals.plos.org
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …

Understanding transgenerational epigenetic inheritance via the gametes in mammals

L Daxinger, E Whitelaw - Nature Reviews Genetics, 2012 - nature.com
It is known that information that is not contained in the DNA sequence—epigenetic
information—can be inherited from the parent to the offspring. However, many questions …

The intergenerational transmission of risk and trust attitudes

T Dohmen, A Falk, D Huffman… - The Review of Economic …, 2012 - academic.oup.com
Recent theories endogenize the attitude endowments of individuals, assuming that they are
shaped by the attitudes of parents and other role models. This paper tests empirically for the …

Plasticity and robustness in development and evolution

P Bateson, P Gluckman - International Journal of Epidemiology, 2012 - academic.oup.com
Biology presents many wonders, but one of the most remarkable is how a complex
multicellular organism grows from a single cell. Until recently, the processes involved …

The role of DNA methylation in aging, rejuvenation, and age-related disease

AA Johnson, K Akman, SRG Calimport… - Rejuvenation …, 2012 - liebertpub.com
DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …