MicroRNAs (miRNAs) are short (∼ 22 nucleotide) RNAs that are important for the regulation
of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly …

The study of IE (immediate-early) gene activation mechanisms has provided numerous
paradigms for how transcription is controlled in response to extracellular signalling. Many of …

The signaling pathways that commit cells to migration are incompletely understood. We
employed human mammary cells and two stimuli: epidermal growth factor (EGF), which …

Stringent regulation of biochemical signalling pathways involves feedback and feedforward
loops, which underlie robust cellular responses to external stimuli. Regulation occurs in all …

RAS mutations are highly relevant for progression and therapy response of human tumours,
but the genetic network that ultimately executes the oncogenic effects is poorly understood …

Presently, neurodegenerative diseases and cancer are the most clinically problematic age-
related diseases worldwide. Although being distinct disorders, their developments share …

MicroRNAs (miRs) function primarily as post-transcriptional negative regulators of gene
expression through binding to their mRNA targets. Reliable prediction of a miR's targets is a …

Molecular Systems Biology 8: 569; published online 14 February 2012; doi: 10.1038/msb.
2012.2 microRNAs (miRNAs) are small, non-coding RNAs that regulate the expression of …

The integrin α6β4 is defined as an adhesion receptor for laminins. Referred to as 'β4', this
integrin plays a key role in the progression of various carcinomas through its ability to …

MicroRNAs have gained significant interest due to their widespread occurrence and diverse
functions as regulatory molecules, which are essential for cell division, growth, development …