Aging is associated with a loss of sex hormone in both men (andropause) and women
(menopause). In men, reductions in testosterone can trigger declines in muscle mass, bone …

Cardiovascular disease (CVD) is more common in men and postmenopausal women (Post-
MW) than premenopausal women (Pre-MW). Despite recent advances in preventive …

Although several lines of evidence have indicated that menopause is associated with
increased susceptibility to neurological disorders, the mechanisms involved in this …

In the mouse, oocytes develop in germline cysts that undergo breakdown resulting in
primordial follicles, consisting of a single oocyte surrounded by granulosa cells. During this …

Neurosteroids are synthesized in the brain and modulate brain excitability. There is
increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their …

Представлены современные сведения о молекулярных механизмах плейотропного
действия эстрогенов в головном мозге. Подробно описаны свойства классических и …

Solid-state {1H} 13C cross-polarization/magic angle spinning (CP/MAS) NMR spectroscopy
has been applied to 17β-estradiol (E2) and 17α-estradiol (E2α), to analyze the steroidal ring …

Estrogen signaling and epigenetic modifications, in particular DNA methylation, are involved
in regulation of gene expression in breast cancers. Here we investigated a potential …

Estrogen receptors α (ERα) and β (ERβ) are nuclear receptors which transduce estradiol
(E2) response in many tissues including the mammary gland and breast cancers (BC). They …

Sex steroid receptors are ligand-triggered transcription factors. Oestrogen, progesterone
and androgen receptors form, together with the glucocorticoid and mineralocorticoid …